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Tramadol

Grade

Acute Analgesia

Therapeutics

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Evidence

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  1. Alici, H.A., Ozmen, I., Cesur, M., Sahin, F., 2003. Effect of the spinal drug tramadol on the fatty acid compositions of rabbit spinal cord and brain. Biol Pharm Bull 26, 1403–1406. https://doi.org/10.1248/bpb.26.1403

  2. Barter, L.S., 2011. Rabbit Analgesia. Veterinary Clinics of North America: Exotic Animal Practice 14, 93–104. https://doi.org/10.1016/j.cvex.2010.09.003

  3. Benato, L., Murrell, J.C., Blackwell, E.J., Saunders, R., Rooney, N., 2020. Analgesia in pet rabbits: a survey study on how pain is assessed and ameliorated by veterinary surgeons. Vet. Rec. https://doi.org/10.1136/vr.105071

  4. Benato, L., Rooney, N.J., Murrell, J.C., 2019. Pain and analgesia in pet rabbits within the veterinary environment: a review. Veterinary Anaesthesia and Analgesia 46, 151–162. https://doi.org/10.1016/j.vaa.2018.10.007

  5. Bloor, M., Paech, M.J., Kaye, R., 2012. Tramadol in pregnancy and lactation. International Journal of Obstetric Anesthesia 21, 163–167. https://doi.org/10.1016/j.ijoa.2011.10.008

  6. Bol’shakov, V.V., Sapozhkov, A.V., Denisova, S.V., 2002. [Effect of droperidol and tramadol combination on the hemostasis in rabbits]. Eksp Klin Farmakol 65, 50–52.

  7. Duvall, A., 2017. Tramadol. Journal of Exotic Pet Medicine 26, 74–77. https://doi.org/10.1053/j.jepm.2016.10.005

  8. Egger, C.M., Souza, M.J., Greenacre, C.B., Cox, S.K., Rohrbach, B.W., 2009. Effect of intravenous administration of tramadol hydrochloride on the minimum alveolar concentration of isoflurane in rabbits. Am J Vet Res 70, 945–949. https://doi.org/10.2460/ajvr.70.8.945

  9. Elyazji, N., Abdel-Aziz, I., Aldalou, A., Shahwan, O., 2013. The Effects of Tramadol Hydrochloride Administration on the Hematological and Biochemical Profiles of domestic male Rabbits. IUG Journal of Natural and Engineering Studies 51–65.

  10. Hamed, M.A., Rizk, M.A., Hafez, A., El–Mahdi, A.S., El-khodery, S.A., 2018. Comparative Effect of Intravenous Administration of Medetomidine, Tramadol, and Medetomidine/Tramadol Combination on Intraocular Pressure (IOP) in Clinically Healthy Donkeys (Equus asinus). Journal of Equine Veterinary Science 69, 16–20. https://doi.org/10.1016/j.jevs.2018.06.001

  11. Ho, S.T., Wan, J.J., Liaw, W.J., Ho, C.M., Li, J.H., 1999. Determination of tramadol by capillary gas chromatography with flame ionization detection. Application to human and rabbit pharmacokinetic studies. J Chromatogr B Biomed Sci Appl 736, 89–96. https://doi.org/10.1016/s0378-4347(99)00434-x

  12. JANG, J.S., KANG, S.S., SON, J.S., LEE, Y.J., KIM, G., CHOI, H.S., 2017. Cortisol Levels and Gastrointestinal Disorders After Stressful Surgery in Rabbits. In Vivo 31, 637–640. https://doi.org/10.21873/invivo.11105

  13. Johnston, M.S., 2005. Clinical Approaches to Analgesia in Ferrets and Rabbits. Seminars in Avian and Exotic Pet Medicine, Anesthesia and Analgesia 14, 229–235. https://doi.org/10.1053/j.saep.2005.09.003

  14. Kaya, T., Gursoy, S., Karadas, B., Sarac, B., Fafali, H., Soydan, A.S., 2003. High-concentration tramadol-induced vasodilation in rabbit aorta is mediated by both endothelium-dependent and -independent mechanisms. Acta Pharmacol Sin 24, 385–389.

  15. Küçük, A., Kadioğlu, Y., Celebi, F., 2005. Investigation of the pharmacokinetics and determination of tramadol in rabbit plasma by a high-performance liquid chromatography-diode array detector method using liquid-liquid extraction. J Chromatogr B Analyt Technol Biomed Life Sci 816, 203–208. https://doi.org/10.1016/j.jchromb.2004.11.031

  16. Lintz, W., Erlaçin, S., Frankus, E., Uragg, H., 1981. [Biotransformation of tramadol in man and animal (author’s transl)]. Arzneimittelforschung 31, 1932–1943.

  17. Mann, N., MacLean, Dr.J., Simone-Freilicher, E., Staudenmaier, A., Lindholm, J., 2019. Pectus Excavatum and Swimmer Puppy Syndrome with Concurrent Congenital Cardiac Anomalies in Two Domestic Rabbits. Journal of Exotic Pet Medicine 29, 212–216. https://doi.org/10.1053/j.jepm.2018.09.017

  18. Marinkovich, M., Guzman, D.S.-M., Hawkins, M.G., Gleeson, M., Chou, P.-Y., 2019. OPEN REDUCTION AND STABILIZATION OF A LUXATED COXOFEMORAL JOINT IN A DOMESTIC RABBIT (ORYCTOLAGUS CUNICULUS) USING A TOGGLE-PIN FIXATION. Journal of Exotic Pet Medicine 30, 43–49. https://doi.org/10.1053/j.jepm.2018.01.009

  19. Müller, B., Wilsmann, K., 1984. Cardiac and hemodynamic effects of the centrally acting analgesics tramadol and pentazocine in anaesthetized rabbits and isolated guinea-pig atria and papillary muscles. Arzneimittelforschung 34, 430–433.

  20. Oguntoye, C.O., Oyewande, O.A., Afolabi, O.O., 2018. Evaluation of Tramadol-Midazolam-Ketamine Anaesthesia in Rabbits. Niger J Physiol Sci 33, 145–149.

  21. Papini, J.Z.B., Cereda, C.M.S., Pedrazzoli Júnior, J., Calafatti, S.A., de Araújo, D.R., Tofoli, G.R., 2017. Pharmacokinetics and Pharmacodynamics Evaluation of Tramadol in Thermoreversible Gels. Biomed Res Int 2017, 5954629. https://doi.org/10.1155/2017/5954629

  22. Pinho, R.H., Leach, M.C., Minto, B.W., Rocha, F.D.L., Luna, S.P.L., 2020. Postoperative pain behaviours in rabbits following orthopaedic surgery and effect of observer presence. PLoS One 15. https://doi.org/10.1371/journal.pone.0240605

  23. Souza, M.J., Cox, S.K., 2011. Tramadol Use in Zoologic Medicine. Veterinary Clinics of North America: Exotic Animal Practice, Analgesia and Pain Management 14, 117–130. https://doi.org/10.1016/j.cvex.2010.09.005

  24. Souza, M.J., Greenacre, C.B., Cox, S.K., 2008. Pharmacokinetics of orally administered tramadol in domestic rabbits (Oryctolagus cuniculus). Am J Vet Res 69, 979–982. https://doi.org/10.2460/ajvr.69.8.979

  25. Swisher, S., Lennox, A., 2015. Analgesia in Small Exotic Mammals: A Review. Advances in Small Animal Medicine and Surgery 28, 1–3. https://doi.org/10.1016/j.asams.2015.11.001

  26. Szkutnik-Fiedler, D., Grabowski, T., Balcerkiewicz, M., Michalak, M., Pilipczuk, I., Wyrowski, Ł., Urjasz, H., Grześkowiak, E., 2017. The influence of a single and chronic administration of venlafaxine on tramadol pharmacokinetics in a rabbit model. Pharmacol Rep 69, 555–559. https://doi.org/10.1016/j.pharep.2017.01.027

  27. Tomacheuski, R.M., Taffarel, M.O., Ferrante, M., Luna, S.P., 2020. Preliminary survey of the attitudes of Brazilian scientists towards pain management and assessment in animals used in science. Vet Anaesth Analg 47, 647–656. https://doi.org/10.1016/j.vaa.2020.05.007

  28. Urrutia, J., Mardones, R., Quezada, F., 2007. The effect of ketoprophen on lumbar spinal fusion healing in a rabbit model. Laboratory investigation. J Neurosurg Spine 7, 631–636. https://doi.org/10.3171/SPI-07/12/631

  29. Vahabzadeh, M., Moshiri, M., Mohammadpour, A.H., Hosseinzadeh, H., 2013. Promising effects of intravenous lipid emulsion as an antidote in acute tramadol poisoning. Reg Anesth Pain Med 38, 425–430. https://doi.org/10.1097/AAP.0b013e31829f644b

  30. Weaver, L.A., Blaze, C.A., Linder, D.E., Andrutis, K.A., Karas, A.Z., 2010. A Model for Clinical Evaluation of Perioperative Analgesia in Rabbits (Oryctolagus cuniculus). J Am Assoc Lab Anim Sci 49, 845–851.

  31. Wenger, S., 2012. Anesthesia and Analgesia in Rabbits and Rodents. Journal of Exotic Pet Medicine, Clinical Anesthesia and Analgesia 21, 7–16. https://doi.org/10.1053/j.jepm.2011.11.010

  32. Yakovleva, A.A., Nazarova, L.A., Prokopenko, V.M., Pavlova, N.G., 2017. Effect of Tramadol on Rabbit Uterine Contractile Activity Induced in Late Pregnancy. Bull Exp Biol Med 162, 349–352. https://doi.org/10.1007/s10517-017-3613-5

  33. Zakaria, A.D., Hayati, F., Azizan, N., Lah, N.A.S.N., Ghazali, M.Z., Mamat, A.Z., Hasan, Z., Salleh, S.M., 2020. The influence of tramadol and parecoxib on erythmyocin or bleomycin-induced pleurodesis in rabbit: A pilot study. Pol. Ann. Med. 28, 28–33. https://doi.org/10.29089/2020.20.00127


Expert Opinion

  1. 1317822 Extrapolation of pharmacological properties in man and veterinary species. Some material employed in collating the data displayed here was taken from veterinary product datasheets or extrapolated from pharmacology texts.



Monograph Details

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