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Meloxicam

Grade

Once Daily Oral Dosing

Therapeutics

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Evidence

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Rabbit Meloxicam Evidence Base

  1. Allweiler, S.I., 2016. How to Improve Anesthesia and Analgesia in Small Mammals. Veterinary Clinics of North America: Exotic Animal Practice 19, 361–377. https://doi.org/10.1016/j.cvex.2016.01.012

  2. Anon, 2014. Meloxicam in Rabbits. Advances in Small Animal Medicine and Surgery 27, 6–7. https://doi.org/10.1016/j.asams.2014.07.006

  3. Barter, L.S., 2011. Rabbit Analgesia. Veterinary Clinics of North America: Exotic Animal Practice 14, 93–104. https://doi.org/10.1016/j.cvex.2010.09.003

  4. Bays, T.B., 2020. Geriatric Care of Rabbits, Guinea Pigs, and Chinchillas. Veterinary Clinics of North America: Exotic Animal Practice, Geriatrics 23, 567–593. https://doi.org/10.1016/j.cvex.2020.05.006

  5. Benato, L., Murrell, J.C., Blackwell, E.J., Saunders, R., Rooney, N., 2020. Analgesia in pet rabbits: a survey study on how pain is assessed and ameliorated by veterinary surgeons. Vet. Rec. https://doi.org/10.1136/vr.105071

  6. Benato, L., Rooney, N.J., Murrell, J.C., 2019. Pain and analgesia in pet rabbits within the veterinary environment: a review. Vet Anaesth Analg 46, 151–162. https://doi.org/10.1016/j.vaa.2018.10.007

  7. Bulliot, C., Flenghi, L., Levrier, C., 2019. Lingual Sarcoma and its Treatment with Partial Glossectomy in a Pet Rabbit (Oryctolagus Cuniculus). Journal of Exotic Pet Medicine 29, 70–75. https://doi.org/10.1053/j.jepm.2018.08.006

  8. Carpenter, J.W., Pollock, C.G., Koch, D.E., Hunter, R.P., 2009. Single and multiple-dose pharmacokinetics of meloxicam after oral administration to the rabbit (Oryctolagus cuniculus). J. Zoo Wildl. Med. 40, 601–606. https://doi.org/10.1638/2007-0115.1

  9. Carrasco, D.C., Minier, K., Shimizu, N., Ragetly, G., Huynh, M., 2018. Surgical Management Of A Traumatic Elbow Luxation With Circumferential Suture Prostheses In A Rabbit (Oryctolagus Cuniculus). Journal of Exotic Pet Medicine 27, 38–42. https://doi.org/10.1053/j.jepm.2018.04.007

  10. Chassang, L., Zoller, G., Loos, P., Gomes, E., Bismuth, C., Briend-Marchal, A., Nicolier, A., Huynh, M., 2019. Antemortem Diagnosis and Surgical Management of Splenitis Due to Yersinia Pseudotuberculosis Infection in a Pet Rabbit (Oryctolagus Cuniculus). Journal of Exotic Pet Medicine 29, 182–187. https://doi.org/10.1053/j.jepm.2018.05.006

  11. Ciwko, E., Sadar, M.J., Bennett, K., Linn, K., 2018. Transfixation Pin Splinting As An Alternative External Coaptation Method In Domestic Rabbit (Oryctolagus Cuniculus) Long Bone Fractures. Journal of Exotic Pet Medicine 27, 31–37. https://doi.org/10.1053/j.jepm.2017.09.004

  12. Cooper, C.S., Metcalf-Pate, K.A., Barat, C.E., Cook, J.A., Scorpio, D.G., 2009. Comparison of Side Effects between Buprenorphine and Meloxicam Used Postoperatively in Dutch Belted Rabbits. Journal of the American Association for Laboratory Animal Science 48, 7.

  13. Coulter, C.A., Flecknell, P.A., Leach, M.C., Richardson, C.A., 2011. Reported analgesic administration to rabbits undergoing experimental surgical procedures. BMC Vet. Res. 7, 12. https://doi.org/10.1186/1746-6148-7-12

  14. Delk, K.W., Carpenter, J.W., KuKanich, B., Nietfeld, J.C., Kohles, M., 2014. Pharmacokinetics of meloxicam administered orally to rabbits (Oryctolagus cuniculus) for 29 days. Am. J. Vet. Res. 75, 195–199. https://doi.org/10.2460/ajvr.75.2.195

  15. Eshar, D., Weese, J.S., 2014. Molecular analysis of the microbiota in hard feces from healthy rabbits (Oryctolagus cuniculus) medicated with long term oral meloxicam. BMC Vet. Res. 10, 62. https://doi.org/10.1186/1746-6148-10-62

  16. Ferris, R.L., Quesenberry, K.E., Weisse, C.W., 2019. Outcome of intraluminal tracheal stent placement for tracheal stenosis in a rabbit (Oryctolagus cuniculus). Journal of Exotic Pet Medicine 31, 23–27. https://doi.org/10.1053/j.jepm.2019.04.017

  17. Fisher, P.G., 2010. Standards of Care in the 21st Century: The Rabbit. Journal of Exotic Pet Medicine 19, 22–35. https://doi.org/10.1053/j.jepm.2010.01.004

  18. Flecknell, P., 2018. Analgesics in Small Mammals. Veterinary Clinics of North America: Exotic Animal Practice, Exotic Animal Neurology 21, 83–103. https://doi.org/10.1016/j.cvex.2017.08.003

  19. Fredholm, D.V., Carpenter, J.W., KuKanich, B., Kohles, M., 2013. Pharmacokinetics of meloxicam in rabbits after oral administration of single and multiple doses. Am. J. Vet. Res. 74, 636–641. https://doi.org/10.2460/ajvr.74.4.636

  20. Gleeson, M., Chen, S., Fabiani, M., Marino, A., Antinoff, N., 2019. Mesenteric Root And Cecal Torsion In A Domestic Rabbit (Oryctolagus Cuniculus). Journal of Exotic Pet Medicine 28, 76–81. https://doi.org/10.1053/j.jepm.2017.11.007

  21. Goldschlager, G.B., Gillespie, V.L., Palme, R., Baxter, M.G., 2013. Effects of Multimodal Analgesia with Low-Dose Buprenorphine and Meloxicam on Fecal Glucocorticoid Metabolites after Surgery in New Zealand White Rabbits (Oryctolagus cuniculus). J Am Assoc Lab Anim Sci 52, 571–576.

  22. Hampshire, V., Robertson, S., 2015. Using the facial grimace scale to evaluate rabbit wellness in post-procedural monitoring. Lab Anim 44, 259–260. https://doi.org/10.1038/laban.806

  23. Hedley, J., Stapleton, N., Muir, C., Priestnall, S., Smith, K., 2019. Cutaneous Botryomycosis In Two Pet Rabbits. Journal of Exotic Pet Medicine 28, 143–147. https://doi.org/10.1053/j.jepm.2018.01.005

  24. Hyde, E.W., Eshar, D., Wright, L., Wilson, M., Roush, J.K., 2019. Surgical correction of grade III medial patellar luxation in a pet rabbit (Oryctolagus cuniculus). Journal of Exotic Pet Medicine 31, 45–48. https://doi.org/10.1053/j.jepm.2019.04.002

  25. Johnston, M.S., 2005. Clinical Approaches to Analgesia in Ferrets and Rabbits. Seminars in Avian and Exotic Pet Medicine 14, 229–235. https://doi.org/10.1053/j.saep.2005.09.003

  26. Karachalios, T., Boursinos, L., Poultsides, L., Khaldi, L., Malizos, K.N., 2007. The effects of the short-term administration of low therapeutic doses of anti-COX-2 agents on the healing of fractures. The Journal of Bone and Joint Surgery. British volume 89-B, 1253–1260. https://doi.org/10.1302/0301-620X.89B9.19050

  27. Keller, K.A., Sanchez-Migallon Guzman, D., Reilly, C., Valentine, B., Duke Boynton, F.D., Scott, E.M., Dubielzig, R.R., 2019. Post-Traumatic Ocular Lymphoma In Three Rabbits (Oryctolagus Cuniculus). Journal of Exotic Pet Medicine 28, 154–161. https://doi.org/10.1053/j.jepm.2018.02.041

  28. Khan, A.M., Rampal, S., 2014. Effects of Repeated Oral Administration of Pazufloxacin Mesylate and Meloxicam on the Antioxidant Status in Rabbits. J Am Assoc Lab Anim Sci 53, 399–403.

  29. Kohn, D.F., Martin, T.E., Foley, P.L., Morris, T.H., Swindle, M.M., Vogler, G.A., Wixson, S.K., 2007. Guidelines for the Assessment and Management of Pain in Rodents and Rabbits. Journal of the American Association for Laboratory Animal Science 46, 12.

  30. Leach, M.C., Allweiler, S., Richardson, C., Roughan, J.V., Narbe, R., Flecknell, P.A., 2009. Behavioural effects of ovariohysterectomy and oral administration of meloxicam in laboratory housed rabbits. Research in Veterinary Science 87, 336–347. https://doi.org/10.1016/j.rvsc.2009.02.001

  31. Lempert, M., 2019. Urinary Obstruction Due to a Prostatic Abscess in a Young Neutered Rabbit. Journal of Exotic Pet Medicine 29, 15–21. https://doi.org/10.1053/j.jepm.2018.10.005

  32. Lennox, A.M., 2010. Care of the Geriatric Rabbit. Veterinary Clinics of North America: Exotic Animal Practice, Geriatrics 13, 123–133. https://doi.org/10.1016/j.cvex.2009.09.002

  33. Lichtenberger, M., Ko, J., 2007. Anesthesia and analgesia for small mammals and birds. Vet Clin North Am Exot Anim Pract 10, 293–315. https://doi.org/10.1016/j.cvex.2006.12.002

  34. Mann, N., MacLean, Dr.J., Simone-Freilicher, E., Staudenmaier, A., Lindholm, J., 2019. Pectus Excavatum and Swimmer Puppy Syndrome with Concurrent Congenital Cardiac Anomalies in Two Domestic Rabbits. Journal of Exotic Pet Medicine 29, 212–216. https://doi.org/10.1053/j.jepm.2018.09.017

  35. Marinkovich, M., Guzman, D.S.-M., Hawkins, M.G., Gleeson, M., Chou, P.-Y., 2019. Open Reduction And Stabilization Of A Luxated Coxofemoral Joint In A Domestic Rabbit (Oryctolagus Cuniculus) Using A Toggle-Pin Fixation. Journal of Exotic Pet Medicine 30, 43–49. https://doi.org/10.1053/j.jepm.2018.01.009

  36. Miwa, Y., Calvo Carrasco, D., 2019. Exotic Mammal Orthopedics. Veterinary Clinics of North America: Exotic Animal Practice, Orthopedics 22, 175–210. https://doi.org/10.1016/j.cvex.2019.02.001

  37. Patel, M., Joshi, A., Hassanzadeth, H., Juluru, R., Stagni, G., 2011. Quantification of dermal and transdermal delivery of meloxicam gels in rabbits. Drug Dev Ind Pharm 37, 613–617. https://doi.org/10.3109/03639045.2010.534098

  38. Paul-Murphy, J., 2007. Critical Care of the Rabbit. Veterinary Clinics of North America: Exotic Animal Practice 10, 437–461. https://doi.org/10.1016/j.cvex.2007.03.002

  39. Raillard, M., Detotto, C., Grepper, S., Beslac, O., Fujioka-Kobayashi, M., Schaller, B., Saulacic, N., 2019. Anaesthetic and Perioperative Management of 14 Male New Zealand White Rabbits for Calvarial Bone Surgery. Animals (Basel) 9. https://doi.org/10.3390/ani9110896

  40. Reimnitz, L., Sanchez-Migallon Guzman, D., LaDouceur, E., Stevens, S., Summa, N., Gardhouse, S., Kol, A., Brust, K., Hawkins, M.G., 2019. Peripheral Nerve Sheath Tumor in the Pelvic Limb of a Domestic Rabbit (Oryctolagus cuniculus). Journal of Exotic Pet Medicine 28, 137–142. https://doi.org/10.1053/j.jepm.2018.04.018

  41. Sabater, M., Calvo Carrasco, D., 2019. Surgical Correction of Traumatic Tarsocrural Joint Luxation in a Rabbit (Oryctolagus Cuniculus). Journal of Exotic Pet Medicine 29, 154–158. https://doi.org/10.1053/j.jepm.2018.10.008

  42. Salhab, A.S., Amro, B.I., Shomaf, M.S., 2003. Further investigation on meloxicam contraceptivity in female rabbits: luteinizing unruptured follicles, a microscopic evidence. Contraception 67, 485–489. https://doi.org/10.1016/s0010-7824(03)00050-7

  43. Salhab, A.S., Gharaibeh, M.N., Shomaf, M.S., Amro, B.I., 2001. Meloxicam inhibits rabbit ovulation. Contraception 63, 329–333. https://doi.org/10.1016/s0010-7824(01)00207-4

  44. Scarabelli, S., Nardini, G., 2020. Gastrointestinal vasculitis and necrosis in a rabbit under long-term meloxicam treatment. Journal of Exotic Pet Medicine. https://doi.org/10.1053/j.jepm.2020.03.014

  45. Stern, H., Sanchez-Migallon Guzman, D., Gleeson, M., Ozawa, S., Liepnieks, M.L., McLarty, E., Johnson, E., Niederhuth, J.H., 2019. Cervical spinal nerve and brachial plexus schwannoma in a rabbit (Oryctolagus cuniculus). Journal of Exotic Pet Medicine 31, 75–78. https://doi.org/10.1053/j.jepm.2019.06.005

  46. Summa, N.M., Brandão, J., 2017. Evidence-Based Advances in Rabbit Medicine. Veterinary Clinics of North America: Exotic Animal Practice 20, 749–771. https://doi.org/10.1016/j.cvex.2017.04.008

  47. Swisher, S., Lennox, A., Vecchio, N., 2020. Tracheal resection and anastomosis for treatment of tracheal collapse in a rabbit. Journal of Exotic Pet Medicine 33, 46–49. https://doi.org/10.1053/j.jepm.2020.02.013

  48. Turner, P.V., Chen, H.C., Taylor, W.M., 2006a. Pharmacokinetics of meloxicam in rabbits after single and repeat oral dosing. Comp. Med. 56, 63–67.

  49. Turner, P.V., Kerr, C.L., Healy, A.J., Taylor, W.M., 2006b. Effect of meloxicam and butorphanol on minimum alveolar concentration of isoflurane in rabbits. Am J Vet Res 67, 770–774. https://doi.org/10.2460/ajvr.67.5.770

  50. Visser, M., 2018. Translating Pharmacokinetic and Pharmacodynamic Data into Practice. Veterinary Clinics of North America: Exotic Animal Practice, Therapeutics 21, 169–182. https://doi.org/10.1016/j.cvex.2018.01.001

  51. Volait-Rosset, L., Pignon, C., Manou, M., Donnelly, T.M., 2019. Surgical Management of a Calcaneus Fracture in a Pet Rabbit. Journal of Exotic Pet Medicine 29, 110–114. https://doi.org/10.1053/j.jepm.2018.11.003

  52. Wenger, S., 2012. Anesthesia and Analgesia in Rabbits and Rodents. Journal of Exotic Pet Medicine 21, 7–16. https://doi.org/10.1053/j.jepm.2011.11.010

  53. Wong, S., Di Girolamo, N., Kuzma, C., Yim, L., Wong, C., Bradley, K., Reavill, D., 2020. Intra-abdominal torsion of a neoplastic testicle in a rabbit (Oryctolagus cuniculus) with cryptorchidism. Journal of Exotic Pet Medicine 33, 38–41. https://doi.org/10.1053/j.jepm.2019.11.008

Expert Opinion

  1. 1317822* |  221003 Extrapolation of pharmacological properties in man and veterinary species. Some material employed in collating the data displayed here was taken from veterinary product datasheets or extrapolated from pharmacology texts.


Last Update 1317822 | 221003

Monograph Details

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