top of page

Ketoprofen

Grade

Analgesia

Therapeutics

Evidence

  1. Audeval-Gerard, C., Nivet, C., el Amrani, A.I., Champeroux, P., Fowler, J., Richard, S., 2000. Pharmacokinetics of ketoprofen in rabbit after a single topical application. Eur J Drug Metab Pharmacokinet 25, 227–230. https://doi.org/10.1007/BF03192319

  2. Blackham, A., Radziwonik, H., 1977. The effect of drugs in established rabbit monoarticular arthritis. Agents Actions 7, 473–480. https://doi.org/10.1007/BF01966856

  3. Cremades, A., Garcia, F., Del Rio, J., Brugger, A.J., 1982. Fever, antipyretics and serum iron levels in rabbits. Eur J Pharmacol 83, 199–205. https://doi.org/10.1016/0014-2999(82)90252-7

  4. Deninger, M.J., Schoenwald, R.D., 2000. Uptake of ibuprofen, indomethacin and ketoprofen into isolated rabbit parietal cells. J Pharm Pharmacol 52, 501–509. https://doi.org/10.1211/0022357001774282

  5. Fujimura, H., Tsurumi, K., Hiramatsu, Y., Go, K., Nakano, K., 1974. [Pharmacological studies on ketoprofen (19583RP). 2. General pharmacological action]. Nihon Yakurigaku Zasshi 70, 801–818.

  6. Guyonnet, J.C., Julou, L., 1976. Relationship between the inhibitory activity on “RCS” and prostaglandins synthesis and the anti-inflammatory activity of ketoprofen and several other non-steroidal anti-inflammatory agents. Rheumatol Rehabil Suppl, 11–14. https://doi.org/10.1093/rheumatology/15.5.11

  7. Imamura, Y., Mori, H., Otagiri, M., 1990. Differential effects of ketoprofen on the pharmacokinetics of sulphadimethoxine in fast and slow acetylator rabbits. J Pharm Pharmacol 42, 62–63. https://doi.org/10.1111/j.2042-7158.1990.tb05353.x

  8. Julou, L., Guyonnet, J.C., Ducrot, R., Pasquet, J., 1976. Some pharmacological and toxicological studies on ketoprofen. Rheumatol Rehabil Suppl, 5–10. https://doi.org/10.1093/rheumatology/15.5.5

  9. Kaller, H., 1979. The pharmacological properties of ketoprofen and its place in antirheumatic therapy. Rheumatol Rehabil Suppl, 99–103. https://doi.org/10.1093/rheumatology/xviii.suppl.99

  10. Kulkarni, P.S., Srinivasan, B.D., 1985. Anti-inflammatory effects of ketoprofen in rabbit corneal epithelial wound model. Exp Eye Res 41, 267–273. https://doi.org/10.1016/s0014-4835(85)80016-6

  11. Kuriyama, K., Hiyama, Y., Aoyama, Y., Ichikawa, K., Okumura, M., Masumoto, S., Ito, K., Ohtaki, Y., Hirata, M., Hanada, S., 1989. [Pharmacological studies of a non-steroidal analgesic and antipyretic drug of LFP83]. Nihon Yakurigaku Zasshi 93, 61–73. https://doi.org/10.1254/fpj.93.61

  12. Lee, B.-S., Choi, Y.-G., Son, W.-C., Jung, K.-M., Kim, J.-J., Kim, B.-H., 2007. Ketoprofen: experimental overview of dermal toxicity. Arch Toxicol 81, 743–748. https://doi.org/10.1007/s00204-007-0199-0

  13. Liao, H., Guo, Y., Jun Na, M., Lane, K.B., Light, R.W., 2007. The short-term administration of Ketoprofen does not decrease the effect of Pleurodesis induced by talc or Doxycycline in rabbits. Respir Med 101, 963–968. https://doi.org/10.1016/j.rmed.2006.09.007

  14. Liu, C., Guan, Y., Tian, Q., Shi, X., Fang, L., 2019. Transdermal enhancement strategy of ketoprofen and teriflunomide: The effect of enhanced drug-drug intermolecular interaction by permeation enhancer on drug release of compound transdermal patch. Int J Pharm 572, 118800. https://doi.org/10.1016/j.ijpharm.2019.118800

  15. Lu, W., Tu, X., Wu, G., 1998. [Studies on the pharmacokinetic-pharmacodynamic model of ketoprofen beta-CD inclusion complex in rabbits]. Yao Xue Xue Bao 33, 855–859.

  16. Lu, W.-L., Zhang, Q., Zheng, L., Wang, H., Li, R.-Y., Zhang, L.-F., Shen, W.-B., Tu, X.-D., 2004. Antipyretic, analgesic and anti-inflammatory activities of ketoprofen beta-cyclodextrin inclusion complexes in animals. Biol Pharm Bull 27, 1515–1520. https://doi.org/10.1248/bpb.27.1515

  17. Mukaide, A., Kameyama, T., 1975. [Anti-inflammatory effects of ketoprofen - with special reference to inhibition of leukocyte migration]. Nihon Yakurigaku Zasshi 71, 553–558.

  18. Perrin, A., Milano, G., Thyss, A., Cambon, P., Schneider, M., 1990. Biochemical and pharmacological consequences of the interaction between methotrexate and ketoprofen in the rabbit. Br J Cancer 62, 736–741. https://doi.org/10.1038/bjc.1990.369

  19. Rorarius, M.G., Baer, G.A., Metsä-Ketelä, T., 1993. The effect of diclofenac and ketoprofen on halothane MAC in rabbit. Agents Actions 38, 286–289. https://doi.org/10.1007/BF01976222

  20. Rotondo, D., Abul, H.T., Milton, A.S., Davidson, J., 1987. The pyrogenic actions of the interferon-inducer, polyinosinic:polycytidylic acid are antagonised by ketoprofen. Eur J Pharmacol 137, 257–260. https://doi.org/10.1016/0014-2999(87)90231-7

  21. Singhai, A.K., Jain, S., Jain, N.K., 1997. Evaluation of an aqueous injection of ketoprofen. Pharmazie 52, 149–151.

  22. Tachizawa, H., Tsukada, W., Saito, T., Akimoto, T., 1977. Prostaglandin synthetase systems in rat and rabbit renal medulla and inhibition by non-steroidal anti-inflammatory drugs. Jpn J Pharmacol 27, 351–359. https://doi.org/10.1254/jjp.27.351

  23. Taylor, P.M., Robertson, S.A., Dixon, M.J., 2007. Evaluation of the use of thermal thresholds to investigate NSAID analgesia in a model of inflammatory pain in cats. Journal of Feline Medicine and Surgery 9, 313–318. https://doi.org/10.1016/j.jfms.2007.03.008

  24. Ueno, K., Masumura, H., Kawamoto, H., Kitagawa, H., 1988. Effects of ketoprofen and other drugs on release of prostaglandins from uterus of rabbits in perinatal period. Res Commun Chem Pathol Pharmacol 59, 141–144.

  25. Urrutia, J., Mardones, R., Quezada, F., 2007. The effect of ketoprophen on lumbar spinal fusion healing in a rabbit model. Laboratory investigation. J Neurosurg Spine 7, 631–636. https://doi.org/10.3171/SPI-07/12/631

  26. Weaver, L.A., Blaze, C.A., Linder, D.E., Andrutis, K.A., Karas, A.Z., 2010. A model for clinical evaluation of perioperative analgesia in rabbits (Oryctolagus cuniculus). J Am Assoc Lab Anim Sci 49, 845–851.

Monograph Details

bottom of page