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Clindamycin

Grade

A safe dose has not been established

  • Enterotoxaemia likely with oral use

Therapeutics

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Evidence

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  1. Borriello, S.P., Carman, R.J., 1983. Association of iota-like toxin and Clostridium spiroforme with both spontaneous and antibiotic-associated diarrhea and colitis in rabbits. J Clin Microbiol 17, 414–418. https://doi.org/10.1128/jcm.17.3.414-418.1983

  2. Carman, R.J., Borriello, S.P., 1984. Infectious nature of Clostridium spiroforme-mediated rabbit enterotoxaemia. Vet Microbiol 9, 497–502. https://doi.org/10.1016/0378-1135(84)90070-1

  3. Fann, M.K., O’Rourke, D., 2001. Normal bacterial flora of the rabbit gastrointestinal tract: A clinical approach. Seminars in Avian and Exotic Pet Medicine 10, 45–47. https://doi.org/10.1053/saep.2001.19794

  4. Gray, J.E., Weaver, R.N., Moran, J., Feenstra, E.S., 1974. The parenteral toxicity of clindamycin 2-phosphate in laboratory animals. Toxicol Appl Pharmacol 27, 308–321. https://doi.org/10.1016/0041-008x(74)90202-6

  5. Hara-Kudo, Y., Morishita, Y., Nagaoka, Y., Kasuga, F., Kumagai, S., 1996. Incidence of diarrhea with antibiotics and the increase of clostridia in rabbits. J Vet Med Sci 58, 1181–1185. https://doi.org/10.1292/jvms.58.12_1181

  6. Katz, L., LaMont, J.T., Trier, J.S., Sonnenblick, E.B., Rothman, S.W., Broitman, S.A., Rieth, S., 1978. Experimental clindamycin-associated colitis in rabbits. Evidence of toxin-mediated mucosal damage. Gastroenterology 74, 246–252.

  7. LaMont, J.T., Sonnenblick, E.B., Rothman, S., 1979. Role of clostridial toxin in the pathogenesis of clindamycin colitis in rabbits. Gastroenterology, 80th Annual Meeting of the American Gastroenterological Association 76, 356–361. https://doi.org/10.1016/0016-5085(79)90346-9

  8. Lees, G.M., Percy, W.H., 1981. Antibiotic-associated colitis: an in vitro investigation of the effects of antibiotics on intestinal motility. Br J Pharmacol 73, 535–547. https://doi.org/10.1111/j.1476-5381.1981.tb10453.x

  9. Lipman, N.S., Weischedel, A.K., Connors, M.J., Olsen, D.A., Taylor, N.S., 1992. Utilization of cholestyramine resin as a preventive treatment for antibiotic (clindamycin) induced enterotoxaemia in the rabbit. Lab Anim 26, 1–8. https://doi.org/10.1258/002367792780809039

Monograph Details

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