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Chloramphenicol

Grade

Sensitive Ocular Infections

Conjunctivitis | Epiphora | Dacryocystitis | Susceptible Infections

  • Ensure any infection is susceptible to the antimicrobial agent

  • Apply one or two drops 4 to 6 times a day for the first 72 hours,  depending on the severity of the condition.

  • Consider flushing through the nasolacrimal ducts under local anaesthesia +/- sedation at regular intervals

  • Consider changes in ventilation and local air quality.

  • Consider the diagnosis and management of any comorbidity such as dental disease

Therapeutics

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Evidence

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  1. Adams, H.R., 1975. Acute adverse effects of antibiotics. J Am Vet Med Assoc 166, 983–987.

  2. Edwards, J.G., Schlech, B.A., 1985. Efficacy of topical chloramphenicol and tobramycin ophthalmic solutions in preventing severe Staphylococcus aureus keratitis in rabbits. Curr Eye Res 4, 821–829. https://doi.org/10.3109/02713688509095248

  3. Guillot, P., Sanders, P., Mourot, D., 1988. [Pharmacokinetic study of chloramphenicol in the rabbit]. Ann Rech Vet 19, 27–33.

  4. Malek, P., Kol’ts, I., Sedlak, I., 1974. [Endotoxic shock and tetracycline antibiotics]. Antibiotiki 19, 1059–1063.

  5. Okerman, L., Devriese, L.A., Gevaert, D., Uyttebroek, E., Haesebrouck, F., 1990a. In vivo activity of orally administered antibiotics and chemotherapeutics against acute septicaemic pasteurellosis in rabbits. Lab Anim 24, 341–344. https://doi.org/10.1258/002367790780865994

  6. Okerman, L., Devriese, L.A., Gevaert, D., Uyttebroek, E., Haesebrouck, F., 1990b. In vivo activity of orally administered antibiotics and chemotherapeutics against acute septicaemic pasteurellosis in rabbits. Lab Anim 24, 341–344. https://doi.org/10.1258/002367790780865994

  7. Sutiak, V., Gustin, P., Delaunois, A., Ansay, M., 1994. Protective effect of chloramphenicol against parathion-induced pulmonary oedema in rabbits: influence of sex. J Vet Pharmacol Ther 17, 77–79. https://doi.org/10.1111/j.1365-2885.1994.tb00526.x

  8. Yeary, R.A., 1975. Systemic toxic effects of chemotherapeutic agents in domestic animals. Vet Clin North Am 5, 51–69. https://doi.org/10.1016/s0091-0279(75)50003-1

Monograph Details

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