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Ampicillin

Grade

Sensitive Infections

10-25 mg/kg, IM, SC, q24h for 5-7d

Therapeutics

Evidence

  1. Beaty, H.N., Walters, E., 1979. Pharmacokinetics of cefamandole and ampicillin in experimental meningitis. Antimicrob Agents Chemother 16, 584–588. https://doi.org/10.1128/AAC.16.5.584

  2. Berté, F., Manzo, L., De Bernardi, M., Benzi, G., 1971. Distribution of ampicillin administered orally in three different forms in rabbit. J Pharm Sci 60, 805–806. https://doi.org/10.1002/jps.2600600536

  3. Börzsei, L., Mintál, T., Koós, Z., Kocsis, B., Helyes, Z., Kereskai, L., Nyárády, J., 2006. Examination of a novel, specified local antibiotic therapy through polymethylmethacrylate capsules in a rabbit osteomyelitis model. Chemotherapy 52, 73–79. https://doi.org/10.1159/000092371

  4. Boyd, C.E., 1960. The acute oral toxicity of benzylpenicillin potassium in the rabbit. Antibiot Chemother (Northfield) 10, 376–384.

  5. Cars, O., 1981a. Tissue distribution of beta-lactam antibiotics. Experimental studies in rabbits. Scand J Infect Dis Suppl Suppl 27, 1–48. https://doi.org/10.3109/inf.1981.13.suppl-27.01

  6. Cars, O., 1981b. Tissue distribution of ampicillin: assays in muscle tissue and subcutaneous tissue cage fluid from normal and nephrectomized rabbits. Scand J Infect Dis 13, 283–289. https://doi.org/10.3109/inf.1981.13.issue-4.09

  7. Cars, O., Ogren, S., 1980. Tissue penetration of ampicillin: parallel determinations of levels in tissue cage fluid and rabbit muscle. J Antimicrob Chemother 6, 408–410. https://doi.org/10.1093/jac/6.3.408

  8. Escoula, L., Camguilhem, R., Larrieu, G., More, J., 1981. [Sensibility of rabbits to treatment with ampicillin and gentamycin (author’s transl)]. Ann Rech Vet 12, 11–17.

  9. Escudero, E., Vicente, M.S., Serrano, J.M., Cárceles, C.M., 2002. Pharmacokinetics of an ampicillin/sulbactam (2:1) combination in rabbits. J Vet Pharmacol Ther 25, 259–264. https://doi.org/10.1046/j.1365-2885.2002.00412.x

  10. Fass, R.J., Wright, C.A., 1984. Comparative efficacies of mezlocillin and ampicillin alone or in combination with gentamicin in the treatment of Streptococcus faecalis endocarditis in rabbits. Antimicrob Agents Chemother 25, 408–410. https://doi.org/10.1128/AAC.25.4.408

  11. Goldman, J.N., Broughton, W., Javed, H., Lauderdale, V., 1973. Ampicillin, erythromycin and chloramphenicol penetration into rabbit aqueous humor. Ann Ophthalmol 5, 147–156.

  12. Guandalini, S., Fasano, A., Migliavacca, M., Verga, M.C., Mastrantonio Gianfrilli, P., Ferrara, A., Alessio, M., Malamisura, B., Galati, P., Pantosti, A., 1988. Pathogenesis of postantibiotic diarrhoea caused by Clostridium difficile: an in vitro study in the rabbit intestine. Gut 29, 598–602. https://doi.org/10.1136/gut.29.5.598

  13. Khurana, C.M., Deddish, P.A., 1983. Effectiveness of treatment with mezlocillin, ampicillin and latamoxef (moxalactam) of experimental group B beta-haemolytic streptococcal meningitis in rabbits. J Antimicrob Chemother 11, 125–133. https://doi.org/10.1093/jac/11.2.125

  14. Law, B.J., Rettig, P.J., Marks, M.I., 1984. Antibiotic therapy of fulminant E. coli K1 sepsis in infant rabbits. Pediatr Res 18, 314–317. https://doi.org/10.1203/00006450-198404000-00002

  15. Licois, D., Coudert, P., Colin, M., 1980. [Attempt to induce diarrhea in young rabbits with different dietary crude fiber contents (author’s transl)]. Ann Rech Vet 11, 279–284.

  16. Morikawa, Y., 1981a. Comparative pharmacokinetics of ampicillin and carbenicillin in the cerebrospinal fluid of rabbits with staphylococcal meningitis with reference to half-lives and areas under the curve. Jpn J Antibiot 34, 211–218.

  17. Morikawa, Y., 1981b. A pharmacokinetic analysis of ampicillin in the cerebrospinal fluid of rabbits with staphylococcal meningitis. Jpn J Antibiot 34, 1178–1184.

  18. Nishimura, K., Nozaki, Y., Yoshimi, A., Nakamura, S., Kitagawa, M., Oketani, T., Kakeya, N., Kitao, K., 1983. [Pharmacokinetics of an ampicillin suppository (KS-R1) in mice, rats and rabbits]. Jpn J Antibiot 36, 1683–1691.

  19. Olfert, E.D., 1981. Ampicillin toxicity in rabbits. Can Vet J 22, 217.

  20. Pinget, M., Brogard, J.M., Dauchel, J., Lavillaureix, J., 1976. Biliary excretion of ampicillin, metampicillin and carbenicillin. J Antimicrob Chemother 2, 195–201. https://doi.org/10.1093/jac/2.2.195

  21. Rehg, J.E., Lu, Y.S., 1981. Clostridium difficile colitis in a rabbit following antibiotic therapy for pasteurellosis. J Am Vet Med Assoc 179, 1296–1297.

  22. Schatzmann, H.J., von Tscharner, C., Tschabold, M., 1977. [Noxious effects of oral treatment of rabbits with ampicillin]. Schweiz Arch Tierheilkd 119, 149–153.

  23. Scheld, W.M., Fletcher, D.D., Fink, F.N., Sande, M.A., 1979. Response to therapy in an experimental rabbit model of meningitis due to Listeria monocytogenes. J Infect Dis 140, 287–294. https://doi.org/10.1093/infdis/140.3.287

  24. Strausbaugh, L.J., Mandaleris, C.D., Sande, M.A., 1977. Cefamandole and ampicillin therapy in experimental Haemophilus influenzae meningitis. J Infect Dis 135, 210–216. https://doi.org/10.1093/infdis/135.2.210

  25. Täuber, M.G., Kunz, S., Zak, O., Sande, M.A., 1989. Influence of antibiotic dose, dosing interval, and duration of therapy on outcome in experimental pneumococcal meningitis in rabbits. Antimicrob Agents Chemother 33, 418–423. https://doi.org/10.1128/AAC.33.4.418

  26. Taylor, W.M., Beaufrère, H., Mans, C., Smith, D.A., 2010. Long-term outcome of treatment of dental abscesses with a wound-packing technique in pet rabbits: 13 cases (1998-2007). J Am Vet Med Assoc 237, 1444–1449. https://doi.org/10.2460/javma.237.12.1444

  27. Tight, R.R., 1980. Ampicillin therapy of experimental enterococcal endocarditis. Antimicrob Agents Chemother 18, 307–310. https://doi.org/10.1128/AAC.18.2.307

  28. Wood, C., 1978. The pet rabbit--veterinary problems. Vet Rec 102, 304–308. https://doi.org/10.1136/vr.102.14.304

Monograph Details

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