top of page

Metoclopramide

Grade

Hypomotility Disorders

See through space
Therapeutics

​

Evidence

​

  1. Ager RVN, L., 2017. Ileus in rabbits – current thinking in treatment, nursing and prevention. Veterinary Nursing Journal 32, 201–205. https://doi.org/10.1080/17415349.2017.1314781

  2. Amadi, C.N., Nwachukwu, W.I., 2020. The effects of oral administration of Cola nitida on the pharmacokinetic profile of metoclopramide in rabbits. BMC Pharmacol Toxicol 21, 4. https://doi.org/10.1186/s40360-019-0379-6

  3. Arita, T., Hori, R., Ito, K., Ichikawa, K., Uesugi, T., 1970. Transformation and excretion of drugs in biological systems. II. Transformation of metoclopramide in rabbits. Chem. Pharm. Bull. 18, 1663–1669. https://doi.org/10.1248/cpb.18.1663

  4. Ashe, J.H., Libet, B., 1981. Modulation of slow postsynaptic potentials by dopamine, in rabbit sympathetic ganglion. Brain Res. 217, 93–106. https://doi.org/10.1016/0006-8993(81)90187-6

  5. Bakke, O.M., Segura, J., 1976. The absorption and elimination of metoclopramide in three animal species. J. Pharm. Pharmacol. 28, 32–39. https://doi.org/10.1111/j.2042-7158.1976.tb04019.x

  6. Birtley, R.D., Baines, M.W., 1973. The effects of metoclopramide on some isolated intestinal preparations. Postgrad Med J 49 Suppl 4, suppl 4:13-18.

  7. Bishop, C.R., 2002. Reproductive medicine of rabbits and rodents. Veterinary Clinics of North America: Exotic Animal Practice 5, 507–535. https://doi.org/10.1016/S1094-9194(02)00019-1

  8. Cohen, M.L., Susemichel, A.D., Bloomquist, W., Robertson, D.W., 1994. 5-HT4 receptors in rat but not guinea pig, rabbit or dog esophageal smooth muscle. Gen Pharmacol 25, 1143–1148. https://doi.org/10.1016/0306-3623(94)90130-9

  9. DeCubellis, J., 2016. Common Emergencies in Rabbits, Guinea Pigs, and Chinchillas. Veterinary Clinics of North America: Exotic Animal Practice 19, 411–429. https://doi.org/10.1016/j.cvex.2016.01.003

  10. DeCubellis, J., Graham, J., 2013. Gastrointestinal Disease in Guinea Pigs and Rabbits. Veterinary Clinics of North America: Exotic Animal Practice, New and Emerging Diseases 16, 421–435. https://doi.org/10.1016/j.cvex.2013.01.002

  11. DeCubellis, J., Kruse, A.M., McCarthy, R.J., Zacher, L.A., Penninck, D., Watson, A.T., Parry, N., Donnelly, T.M., Mayer, J., 2010. Biliary Cystadenoma in a Rabbit (Oryctolagus cuniculus). Journal of Exotic Pet Medicine, Cutting Edge Avian/Exotic Medicine and Surgery 19, 177–182. https://doi.org/10.1053/j.jepm.2010.05.001

  12. Di Giuseppe, M., Faraci, L., Luparello, M., Morici, M., Dorrestein, G.M., Spadola, F., 2016. Omental Torsion in a Rabbit (Oryctolagus cuniculus). Journal of Exotic Pet Medicine 25, 163–167. https://doi.org/10.1053/j.jepm.2016.03.008

  13. Elliott, P., Seemungal, B.M., Wallis, D.I., 1990. Antagonism of the effects of 5-hydroxytryptamine on the rabbit isolated vagus nerve by BRL 43694 and metoclopramide. Naunyn Schmiedebergs Arch. Pharmacol. 341, 503–509. https://doi.org/10.1007/BF00171729

  14. Elliott, P., Wallis, D.I., 1990. Analysis of the actions of 5-hydroxytryptamine on the rabbit isolated vagus nerve. Naunyn Schmiedebergs Arch. Pharmacol. 341, 494–502. https://doi.org/10.1007/BF00171728

  15. Gupta, R., Sadhna,  null, Kulshrestha, V.K., Prasad, D.N., 1985. Pharmacological studies on metoclopramide. Indian J. Med. Res. 82, 463–467.

  16. Guzman, D.S.-M., Graham, J.E., Keller, K., Hunt, G., Tong, N., Morrisey, J.K., 2015. Colonic Obstruction Following Ovariohysterectomy in Rabbits: 3 Cases. Journal of Exotic Pet Medicine, Neurology 24, 112–119. https://doi.org/10.1053/j.jepm.2014.11.006

  17. Harcourt-Brown, T.R., 2007. Management of Acute Gastric Dilation in Rabbits. Journal of Exotic Pet Medicine 16, 168–174. https://doi.org/10.1053/j.jepm.2007.06.004

  18. Hedley, J., 2011. Critical care of the rabbit. In Practice 33, 386–391. https://doi.org/10.1136/inp.d4922

  19. Huynh, M., Pignon, C., 2013. Gastrointestinal Disease in Exotic Small Mammals. J Exot Pet Med 22, 118–131. https://doi.org/10.1053/j.jepm.2013.05.004

  20. Keeble, E.J., 2007. Clinical snapshot. Polyuria, polydipsia, and glycosuria in a white rabbit. Compend Contin Educ Vet 29, 103, 106.

  21. King, C., 2009. Post-operative Nursing Care of the Rabbit Patient. Veterinary Nursing Journal 24, 24–25. https://doi.org/10.1080/17415349.2009.11013065

  22. Lamb, S., 2017. Large bowel resection and anastomosis in a domestic rabbit following obstruction. Journal of Exotic Pet Medicine 26, 224–229. https://doi.org/10.1053/j.jepm.2017.05.002

  23. Langer, J.C., Bramlett, G., 1997. Effect of prokinetic agents on ileal contractility in a rabbit model of gastroschisis. J. Pediatr. Surg. 32, 605–608. https://doi.org/10.1016/s0022-3468(97)90717-x

  24. Lee, H.W., Machin, H., Adami, C., 2018. Peri-anaesthetic mortality and nonfatal gastrointestinal complications in pet rabbits: a retrospective study on 210 cases. Veterinary Anaesthesia and Analgesia 45, 520–528. https://doi.org/10.1016/j.vaa.2018.01.010

  25. Lichtenberger, M., Lennox, A., 2010. Updates and Advanced Therapies for Gastrointestinal Stasis in Rabbits. Veterinary Clinics of North America: Exotic Animal Practice 13, 525–541. https://doi.org/10.1016/j.cvex.2010.05.008

  26. Lord, B., 2012a. Gastrointestinal disease in rabbits 1. Gastric diseases. In Practice 34, 90–96. https://doi.org/10.1136/inp.e328

  27. Lord, B., 2012b. Gastrointestinal disease in rabbits 2. Intestinal diseases. In Practice 34, 156–162. https://doi.org/10.1136/inp.e973

  28. Mahajan, H.S., Gattani, S., 2010. In situ gels of Metoclopramide Hydrochloride for intranasal delivery: in vitro evaluation and in vivo pharmacokinetic study in rabbits. Drug Deliv 17, 19–27. https://doi.org/10.3109/10717540903447194

  29. Marzano, L.A., Lobello, R., Marone, G., Colantuoni, A., 1975. [Influence of several drugs on intestinal motility]. Boll. Soc. Ital. Biol. Sper. 51, 1104–1108.

  30. Meredith, A., Rayment, L., 2000. Liver disease in rabbits. Seminars in Avian and Exotic Pet Medicine 9, 146–152. https://doi.org/10.1053/ax.2000.7135

  31. Mouillé, P., Cheymol, G., Gadbin, C., 1977. [Cardiovascular and hemodynamic effects of two derivatives of metoclopramide (bromopride and MUS 1880)]. Ann Pharm Fr 35, 53–63.

  32. Oglesbee, B.L., Lord, B., 2020. Gastrointestinal Diseases of Rabbits. Ferrets, Rabbits, and Rodents 174–187. https://doi.org/10.1016/B978-0-323-48435-0.00014-9

  33. Okwuasaba, F.K., Hamilton, J.T., 1976. The effect of metoclopramide on intestinal muscle responses and the peristaltic reflex in vitro. Can. J. Physiol. Pharmacol. 54, 393–404. https://doi.org/10.1139/y76-055

  34. Okwuasaba, F.K., Hamilton, J.T., 1975. The effect of metoclopramide on inhibition induced by purine nucleotides, noradrenaline, and theophylline ethylenediamine on intestinal muscle and on peristalsis in vitro. Can. J. Physiol. Pharmacol. 53, 972–977. https://doi.org/10.1139/y75-135

  35. Paul-Murphy, J., 2007. Critical Care of the Rabbit. Veterinary Clinics of North America: Exotic Animal Practice, Emergency and Critical Care 10, 437–461. https://doi.org/10.1016/j.cvex.2007.03.002

  36. Paul-Murphy, J., Ramer, J.C., 1998. Urgent Care of the Pet Rabbit. Veterinary Clinics of North America: Exotic Animal Practice, Critical Care 1, 127–152. https://doi.org/10.1016/S1094-9194(17)30158-5

  37. Pizzi, R., Hagen, R.U., Meredith, A.L., 2007. Intermittent Colic and Intussusception Due to a Cecal Polyp in a Rabbit. Journal of Exotic Pet Medicine, Ophthalmology 16, 113–117. https://doi.org/10.1053/j.jepm.2007.03.007

  38. Rao, N., Otis, K.W., Hwang, K.K., 1992. Sex-differences in the disposition of substituted benzamides: pharmacokinetics of a gastroprokinetic agent (4-amino-5-chloro-2-[2- (methylsulfinyl) ethoxy]-N-[2-(diethylamino)ethyl] benzamide hydrochloride) (ML-1035) in male and female New Zealand white rabbits. Biopharm Drug Dispos 13, 681–691. https://doi.org/10.1002/bdd.2510130906

  39. Redrobe, S., 2002. Soft tissue surgery of rabbits and rodents. Seminars in Avian and Exotic Pet Medicine, Soft Tissue Surgery 11, 231–245. https://doi.org/10.1053/saep.2002.126570

  40. Reusch, B., 2005. Rabbit Gastroenterology. Veterinary Clinics of North America: Exotic Animal Practice, Gastroenterology 8, 351–375. https://doi.org/10.1016/j.cvex.2005.01.007

  41. Rich, G.A., 2002. Rabbit orthopedic surgery. Veterinary Clinics of North America: Exotic Animal Practice, Orthopedics 5, 157–168. https://doi.org/10.1016/S1094-9194(03)00051-3

  42. Ritzman, T.K., 2014. Diagnosis and Clinical Management of Gastrointestinal Conditions in Exotic Companion Mammals (Rabbits, Guinea Pigs, and Chinchillas). Veterinary Clinics of North America: Exotic Animal Practice, Gastroenterology 17, 179–194. https://doi.org/10.1016/j.cvex.2014.01.003

  43. Sanger, G.J., Broad, J., Andrews, P.L.R., 2013. The relationship between gastric motility and nausea: Gastric prokinetic agents as treatments. European Journal of Pharmacology 715, 10–14. https://doi.org/10.1016/j.ejphar.2013.06.031

  44. Sowers, J.R., Sharp, B., Levin, E.R., Golub, M.S., Eggena, P., 1981. Metoclopramide, a dopamine antagonist, stimulates aldosterone secretion in rhesus monkeys but not in dogs or rabbits. Life Sci. 29, 2171–2175. https://doi.org/10.1016/0024-3205(81)90487-2

  45. Summa, N.M., Brandão, J., 2017. Evidence-Based Advances in Rabbit Medicine. Veterinary Clinics of North America: Exotic Animal Practice, Evidence-Based Clinical Practice in Exotic Animal Medicine 20, 749–771. https://doi.org/10.1016/j.cvex.2017.04.008

  46. Taylor, H.R., Staff, C.D., 2007. Clinical Techniques: Successful Management of Liver Lobe Torsion in a Domestic Rabbit (Oryctolagus cuniculus) by Surgical Lobectomy. Journal of Exotic Pet Medicine, Rabbits 16, 175–178. https://doi.org/10.1053/j.jepm.2007.06.005

  47. Vito, V.D., Kim, T.-W., Rota, S., Giorgi, M., 2015. Pharmacokinetics of Metoclopramide After IntraARTERIAL, Intramuscular, Subcutaneous, and Perrectal Administration in Rabbits. Journal of Exotic Pet Medicine, Fungal Infections 24, 361–366. https://doi.org/10.1053/j.jepm.2015.06.018

  48. Wenger, S., 2012. Anesthesia and Analgesia in Rabbits and Rodents. Journal of Exotic Pet Medicine, Clinical Anesthesia and Analgesia 21, 7–16. https://doi.org/10.1053/j.jepm.2011.11.010

Monograph Details

​

bottom of page