Cannabidiol
Analgesia
Indications
Appropriate indications for the rabbit are not yet agreed upon.
Cannabidiol is a popular active substance employed by lay people in the management of chronic pain, neuropathic pain and seizures in major pet species and man.
Suggested MSE Dose Range
1-15mgkg, PO, q12-24h; typical staring dose is 2.5 mg/kg, PO, q12h.
Effective doses for rabbits appear higher than those being administered to and considered suitable for canine patients (Isaev et al., 2022; Rooney et al., 2022).
In major species 2.5 mg/kg, PO, q12h is commonly employed alongside traditional therapy.
Verrico CD, Wesson S, Konduri V, et al. A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain. Pain. 2020;161(9):2191-2202.
McGrath S, Bartner LR, Rao S, Packer RA, Gustafson DL. Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy. J Am Vet Med Assoc. 2019;254(11):1301-1308.
Isaev, D., Shabbir, W., Dinc, E.Y., Lorke, D.E., Petroianu, G., Oz, M., 2022. Cannabidiol Inhibits Multiple Ion Channels in Rabbit Ventricular Cardiomyocytes. Front Pharmacol 13, 821758. https://doi.org/10.3389/fphar.2022.821758
Rooney, T.A., Carpenter, J.W., KuKanich, B., Gardhouse, S.M., Magnin, G.C., Tully, T.N., 2022. Feeding decreases the oral bioavailability of cannabidiol and cannabidiolic acid in hemp oil in New Zealand White rabbits (Oryctolagus cuniculus). Am J Vet Res 83, ajvr.22.01.0006. https://doi.org/10.2460/ajvr.22.01.0006