Dosing Options

KM

1. Preoxygenate: Place in an oxygen chamber before sedation commences

2. Induce: Ketamine 2.5–5 mg/kg IV + Midazolam 0.5 mg/kg IV

3. Intubation: Subsequent use of a volatile agent (e.g. Isoflurane) with suplementary oxygen is recommended

MMK

1. Preoxygenate: Place in an oxygen chamber before sedation commences

2. Induce Option 1: Medetomidine 0.1 mg/kg + Midazolam 1 mg/kg + Ketamine 10 mg/kg, together IM

3. Induce Option 2: Medetomidine 0.1 mg/kg + Midazolam 1 mg/kg  together IM with staggered/delayed Ketamine 10 mg/kg IV

4. Intubation: Subsequent use of a volatile agent (e.g. Isoflurane) with suplementary oxygen is recommended

5. Reversal: Atipamezole 0.25mg/kg IM (2.5 X Medetomidine dose = half Medetomidine volume)

References: (Astuto et al., 2001; Atalan et al., 2019; Bellini et al., 2014; Borkowski et al., 1990; Botman et al., 2020; Cardoso et al., 2020; Chen et al., 2018; Dupras et al., 2001; Fontes-Sousa et al., 2009; Grint and Murison, 2008, 2007; Henke et al., 2005; Kirihara et al., 2019; Kohjitani et al., 2003; Lee et al., 2019; Malinovsky et al., 1991; Oguntoye et al., 2018; Petry et al., 1990; Raulic et al., 2021; Robertson and Eberhart, 1994; Troitzsch et al., 1995; Vachon et al., 1999)