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Paracetamol

Grade

Peri-Operative Analgesia

Therapeutics

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Evidence

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  1. Benato, L., Rooney, N.J., Murrell, J.C., 2019. Pain and analgesia in pet rabbits within the veterinary environment: a review. Veterinary Anaesthesia and Analgesia 46, 151–162. https://doi.org/10.1016/j.vaa.2018.10.007

  2. De Beer, J.O., Jacobs, G.A., Janssens, G., Martens, M.A., 1985. Impact of dilution on the pharmacokinetic behavior of acetaminophen in rabbits after oral administration. J Pharm Sci 74, 325–327. https://doi.org/10.1002/jps.2600740321

  3. Karbownik, A., Bienert, A., Płotek, W., Grabowski, T., Cerbin-Koczorowska, M., Wolc, A., Grześkowiak, E., 2017. Influence of the Time of Intravenous Administration of Paracetamol on its Pharmacokinetics and Ocular Disposition in Rabbits. Eur J Drug Metab Pharmacokinet 42, 489–498. https://doi.org/10.1007/s13318-016-0365-y

  4. Lubek, B.M., Avaria, M., Basu, P.K., Wells, P.G., 1988. Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. Fundam Appl Toxicol 10, 596–606. https://doi.org/10.1016/0272-0590(88)90186-8

  5. Maciejewska-Paszek, I., Pawłowska-Góral, K., Kostrzewski, M., Kurzeja, E., Wardas, M., Rzepecka-Stojko, A., 2007. The influence of small doses of paracetamol on rabbit liver. Exp. Toxicol. Pathol. 59, 139–141. https://doi.org/10.1016/j.etp.2007.04.003

  6. McNamara, P.J., Burgio, D., Yoo, S.D., 1991. Pharmacokinetics of acetaminophen, antipyrine, and salicylic acid in the lactating and nursing rabbit, with model predictions of milk to serum concentration ratios and neonatal dose. Toxicol. Appl. Pharmacol. 109, 149–160. https://doi.org/10.1016/0041-008x(91)90198-n

  7. Schweizer, A., Brom, R., 1985. Differentiation of peripheral and central effects of analgesic drugs. Int J Tissue React 7, 79–83.

  8. Zira, A., Mikros, E., Giannioti, K., Galanopoulou, P., Papalois, A., Liapi, C., Theocharis, S., 2009. Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum. J Appl Toxicol 29, 395–402. https://doi.org/10.1002/jat.1425


Expert Opinion

  1. 1317822* |  220805 Extrapolation of pharmacological properties in man and veterinary species. Some material employed in collating the data displayed here was taken from veterinary product datasheets or extrapolated from pharmacology texts.


Monograph Details

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