top of page

Torasemide

Grade

Diuretic

Suggested Dosing

  • Diuresis:  0.13 to 0.25 mg/kg q24h  (Ref). There is limited evidence to recommend this dosing schedule. We therefore give weak recommendations only. 

  • Efficacy: The available evidence supports some degree of efficacy and suitability of the agent in situations where furosemide use is unavailable or unsuitable.

Therapeutics

​

Evidence

​

  1. Dubourg, L., Drukker, A., Guignard, J.P., 2000a. Failure of the loop diuretic torasemide to improve renal function of hypoxemic vasomotor nephropathy in the newborn rabbit. Pediatr Res 47, 504–508. https://doi.org/10.1203/00006450-200004000-00015

  2. Dubourg, L., Mosig, D., Drukker, A., Guignard, J.P., 2000b. Torasemide is an effective diuretic in the newborn rabbit. Pediatr Nephrol 14, 476–479. https://doi.org/10.1007/s004670050796

  3. Greger, R., 1988. Inhibition of active NaCl reabsorption in the thick ascending limb of the loop of Henle by torasemide. Arzneimittelforschung 38, 151–152.

  4. Kim, Y.C., Lee, M.G., Ko, S.-H., Kim, S.H., 2004. Effect of intravenous infusion time on the pharmacokinetics and pharmacodynamics of the same total dose of torasemide in rabbits. Biopharmaceutics & Drug Disposition 25, 211–218. https://doi.org/10.1002/bdd.401

  5. Kim, Y.C., Lee, M.G., Ko, S.-H., Kim, S.H., 2003. Effects of the rate and composition of fluid replacement on the pharmacokinetics and pharmacodynamics of intravenous torasemide. J Pharm Pharmacol 55, 1515–1522. https://doi.org/10.1211/0022357022034

Monograph Details

​

bottom of page