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Metronidazole

Grade

Sensitive Infections

Therapeutics

Evidence

  1. Bhatt, P.P., Nimbkar, A.Y., 1988. Oral absorption of metronidazole in rabbits irradiated with cobalt-60 gamma radiation. J Pharm Pharmacol 40, 296–297. https://doi.org/10.1111/j.2042-7158.1988.tb05251.x

  2. Buttar, H.S., 1982. Fate of metronidazole following intravaginal and intravenous administration to rabbits. J Toxicol Environ Health 9, 305–316. https://doi.org/10.1080/15287398209530163

  3. Chandrasekar, P.H., Rolston, K.V., Chokkavelu, V., Le Frock, J.L., Kannangara, D.W., 1984. Comparative efficacy of four antibiotics in anaerobic pulmonary infection. An experimental model in rabbits. Chemotherapy 30, 331–336. https://doi.org/10.1159/000238289

  4. Jekl, V., Piskovska, A., Drnkova, I., Skoric, M., Hauptman, K., Chloupek, J., 2021. Case Report: Spontaneous Appendicitis With Suspected Involvement of Klebsiella variicola in Two Pet Rabbits. Front Vet Sci 8, 779517. https://doi.org/10.3389/fvets.2021.779517

  5. Johansson, A., Eliasson, G., Svensson, O., Nord, C.E., 1991. Anaerobic osteomyelitis--treatment with metronidazole in an experimental rabbit model. Drugs Exp Clin Res 17, 299–304.

  6. Kohli, J., Bhattacharya, S.K., Gupta, V.S., Sen, P., Chakravarty, A.K., 1987. Effect of metronidazole on immune mechanism in experimental animals. Indian J Exp Biol 25, 177–180.

  7. Lees, G.M., Percy, W.H., 1981. Antibiotic-associated colitis: an in vitro investigation of the effects of antibiotics on intestinal motility. Br J Pharmacol 73, 535–547. https://doi.org/10.1111/j.1476-5381.1981.tb10453.x

  8. Longo, M., Thierry, F., Eatwell, K., Schwarz, T., del Pozo, J., Richardson, J., 2018. Ultrasound and computed tomography of sacculitis and appendicitis in a rabbit. Veterinary Radiology & Ultrasound 59, E56–E60. https://doi.org/10.1111/vru.12602

  9. Ma, W.-J., Wu, Z.-R., Yang, Q., Hu, H.-J., Wang, J.-K., Shi, Y.-J., Li, F.-Y., Cheng, N.-S., 2020. Biliary antibiotics irrigation for E. coli-induced chronic proliferative cholangitis and hepatolithiasis: A pathophysiological study in rabbits. Clin Res Hepatol Gastroenterol 44, 356–367. https://doi.org/10.1016/j.clinre.2019.07.008

  10. Moody, J.A., Fasching, C.E., Sinn, L.M., Gerding, D.N., Peterson, L.R., 1990. Comparative efficacy of cefoperazone, cefoperazone plus sulbactam, ciprofloxacin, clindamycin, metronidazole, and penicillin G against anaerobic bacteria in an animal model. J Lab Clin Med 115, 190–195.

  11. Reusch, B., 2005. Rabbit Gastroenterology. Vet Clin North Am Exot Anim Pract 8, 351–375. https://doi.org/10.1016/j.cvex.2005.01.007

  12. Roe, F.J., 1983. Toxicologic evaluation of metronidazole with particular reference to carcinogenic, mutagenic, and teratogenic potential. Surgery 93, 158–164.

  13. Senemar, S., Kuzma, B.A., Ramezanli, T., Ghosh, P., Raney, S.G., Rantou, E., Stagni, G., 2023. Bioequivalence Evaluation of Topical Metronidazole Products Using Dermal Microdialysis in New Zealand Rabbits. AAPS PharmSciTech 24, 204. https://doi.org/10.1208/s12249-023-02660-2

  14. Simopoulos, C., Kouskoukis, C., Polychronides, A., Bezirtzoglou, E., 1994. Effect of different combinations of antibiotics on experimental septic peritonitis in rabbits. Int J Clin Lab Res 24, 167–170. https://doi.org/10.1007/BF02592448

Monograph Details

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