top of page

Florfenicol

Grade

Sensitive Infections

Therapeutics

Evidence

  1. Abd El-Aty, A.M., Goudah, A., Abo El-Sooud, K., El-Zorba, H.Y., Shimoda, M., Zhou, H.H., 2004. Pharmacokinetics and bioavailability of florfenicol following intravenous, intramuscular and oral administrations in rabbits. Vet Res Commun 28, 515–524. https://doi.org/10.1023/b:verc.0000040241.06642.49

  2. Cazanga, V., Palma, C., Casanova, T., Barrera, K., Valenzuela, C., Acevedo, A., Pérez-Fernández, R., 2023a. Plasma disposition of florfenicol after intramuscular administration in rabbits pretreated with pentoxifylline. J Vet Pharmacol Ther 46, 195–199. https://doi.org/10.1111/jvp.13117

  3. Cazanga, V., Palma, C., Casanova, T., Rojas, D., Barrera, K., Valenzuela, C., Acevedo, A., Ascui-Gac, G., Pérez-Jeldres, T., Pérez-Fernández, R., 2023b. Modulation of the Acute Inflammatory Response Induced by the Escherichia coli Lipopolysaccharide through the Interaction of Pentoxifylline and Florfenicol in a Rabbit Model. Antibiotics (Basel) 12, 639. https://doi.org/10.3390/antibiotics12040639

  4. Farag, V.M., El-Shafei, R.A., Elkenany, R.M., Ali, H.S., Eladl, A.H., 2022. Antimicrobial, immunological and biochemical effects of florfenicol and garlic (Allium sativum) on rabbits infected with Escherichia coli serotype O55: H7. Vet Res Commun 46, 363–376. https://doi.org/10.1007/s11259-021-09859-3

  5. Huybens, N., Houeix, J., Licois, D., Mainil, J., Marlier, D., 2011. Epizootic rabbit enteropathy inoculum (TEC4): antibiograms and antibiotic fractionation. Vet Res Commun 35, 13–20. https://doi.org/10.1007/s11259-010-9446-6

  6. Koc, F., Ozturk, M., Kadioglu, Y., Dogan, E., Yanmaz, L.E., Okumus, Z., 2009. Pharmacokinetics of florfenicol after intravenous and intramuscular administration in New Zealand White rabbits. Res Vet Sci 87, 102–105. https://doi.org/10.1016/j.rvsc.2008.10.010

  7. Liu, C., Wang, S.-J., Zhang, Q., Shao, Y.-X., 2015. Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits. Exp Anim 64, 73–79. https://doi.org/10.1538/expanim.14-0064

  8. Liu, N., Guo, M., Mo, F., Sun, Y.-H., Yuan, Z., Cao, L.-H., Jiang, S.-X., 2012. Involvement of P-glycoprotein and cytochrome P450 3A in the metabolism of florfenicol of rabbits. J Vet Pharmacol Ther 35, 202–205. https://doi.org/10.1111/j.1365-2885.2011.01310.x

  9. Park, B.-K., Lim, J.-H., Kim, M.-S., Hwang, Y.-H., Yun, H.-I., 2007. Pharmacokinetics of florfenicol and its major metabolite, florfenicol amine, in rabbits. J Vet Pharmacol Ther 30, 32–36. https://doi.org/10.1111/j.1365-2885.2007.00809.x

  10. Pérez, R., Palma, C., Burgos, R., Jeldres, J.A., Espinoza, A., Peñailillo, A.K., 2016. The acute phase response induced by Escherichia coli lipopolysaccharide modifies the pharmacokinetics and metabolism of florfenicol in rabbits. J Vet Pharmacol Ther 39, 183–190. https://doi.org/10.1111/jvp.12244

  11. Ren, S.Y., Geng, Y., Wang, K.Y., Zhou, Z.Y., Liu, X.X., He, M., Peng, X., Wu, C.Y., Lai, W.M., 2014. Streptococcus agalactiae infection in domestic rabbits, Oryctolagus cuniculus. Transbound Emerg Dis 61, e92-95. https://doi.org/10.1111/tbed.12073

Monograph Details

bottom of page