top of page

Cisapride

Grade

Hypomotility Disorders

Therapeutics

​

Evidence

​

Cisapride | Rabbit | Literature Review

  1. Ager RVN, L., 2017. Ileus in rabbits – current thinking in treatment, nursing and prevention. Veterinary Nursing Journal 32, 201–205. https://doi.org/10.1080/17415349.2017.1314781

  2. DeCubellis, J., 2016. Common Emergencies in Rabbits, Guinea Pigs, and Chinchillas. Veterinary Clinics of North America: Exotic Animal Practice 19, 411–429. https://doi.org/10.1016/j.cvex.2016.01.003

  3. DeCubellis, J., Graham, J., 2013. Gastrointestinal Disease in Guinea Pigs and Rabbits. Vet Clin North Am Exot Anim Pract 16, 421–435. https://doi.org/10.1016/j.cvex.2013.01.002

  4. Dumotier, B.M., Bastide, M., Adamantidis, M.M., 2001. “Use-dependent” effects of cisapride on postrest action potentials in rabbit ventricular myocardium. Eur. J. Pharmacol. 422, 137–148. https://doi.org/10.1016/s0014-2999(01)01062-7

  5. Feldman, E.R., Singh, B., Mishkin, N.G., Lachenauer, E.R., Martin-Flores, M., Daugherity, E.K., 2021. Effects of Cisapride, Buprenorphine, and Their Combination on Gastrointestinal Transit in New Zealand White Rabbits. J Am Assoc Lab Anim Sci 60, 221–228. https://doi.org/10.30802/AALAS-JAALAS-20-000064

  6. Gibson, D., 1999. A review of the adverse effects of Cisapride. J Ark Med Soc 95, 384–386.

  7. Harcourt-Brown, T.R., 2007. Management of Acute Gastric Dilation in Rabbits. Journal of Exotic Pet Medicine 16, 168–174. https://doi.org/10.1053/j.jepm.2007.06.004

  8. Hedley, J., 2011. Critical care of the rabbit. In Practice 33, 386–391. https://doi.org/10.1136/inp.d4922

  9. Hubbard, P.M., 1994. Cisapride. ANNA J 21, 374–375, 380.

  10. Huynh, M., Pignon, C., 2013. Gastrointestinal Disease in Exotic Small Mammals. J Exot Pet Med 22, 118–131. https://doi.org/10.1053/j.jepm.2013.05.004

  11. King, C., 2009. Post-operative Nursing Care of the Rabbit Patient. Veterinary Nursing Journal 24, 24–25. https://doi.org/10.1080/17415349.2009.11013065

  12. Koutsoviti-Papadopoulou, M., Nikolaidis, E., Batzias, G.C., Kounenis, G., 2001. Synergistic and antagonistic pharmacodynamic interaction between ranitidine and cisapride: a study on the isolated rabbit intestine. Pharmacological Research 43, 329–334. https://doi.org/10.1006/phrs.2000.0785

  13. Lamb, S., 2017. Large bowel resection and anastomosis in a domestic rabbit following obstruction. Journal of Exotic Pet Medicine 26, 224–229. https://doi.org/10.1053/j.jepm.2017.05.002

  14. Langer, J.C., Bramlett, G., 1997. Effect of prokinetic agents on ileal contractility in a rabbit model of gastroschisis. J. Pediatr. Surg. 32, 605–608. https://doi.org/10.1016/s0022-3468(97)90717-x

  15. Lauritsen, K., Laursen, L.S., Rask-Madsen, J., 1990. Clinical pharmacokinetics of drugs used in the treatment of gastrointestinal diseases (Part II). Clin Pharmacokinet 19, 94–125. https://doi.org/10.2165/00003088-199019020-00002

  16. Lichtenberger, M., 2007. Rabbit Gastrointestinal Stasis Treated with NG Tube Feeding 5.

  17. Lichtenberger, M., Lennox, A., 2010. Updates and Advanced Therapies for Gastrointestinal Stasis in Rabbits. Veterinary Clinics of North America: Exotic Animal Practice 13, 525–541. https://doi.org/10.1016/j.cvex.2010.05.008

  18. Longo, M., Thierry, F., Eatwell, K., Schwarz, T., del Pozo, J., Richardson, J., 2018. Ultrasound and computed tomography of sacculitis and appendicitis in a rabbit. Vet Radiol Ultrasound 59, E56–E60. https://doi.org/10.1111/vru.12602

  19. Lord, B., 2012a. Gastrointestinal disease in rabbits 1. Gastric diseases. In Practice 34, 90–96. https://doi.org/10.1136/inp.e328

  20. Lord, B., 2012b. Gastrointestinal disease in rabbits 2. Intestinal diseases. In Practice 34, 156–162. https://doi.org/10.1136/inp.e973

  21. Mans, C., Fink, D.M., Ciarrocchi, C., 2021. Effects of oral cisapride administration in chinchillas (Chinchilla lanigera) with experimentally induced fecal output reduction. Journal of Exotic Pet Medicine 38, 21–25. https://doi.org/10.1053/j.jepm.2021.04.003

  22. McCallum, R.W., Prakash, C., Campoli-Richards, D.M., Goa, K.L., 1988. Cisapride. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders. Drugs 36, 652–681. https://doi.org/10.2165/00003495-198836060-00002

  23. Michalets, E.L., Williams, C.R., 2000. Drug interactions with cisapride: clinical implications. Clin Pharmacokinet 39, 49–75. https://doi.org/10.2165/00003088-200039010-00004

  24. Michiels, M., Monbaliu, J., Hendriks, R., Geerts, R., Woestenborghs, R., Heykants, J., 1987. Pharmacokinetics and tissue distribution of the new gastrokinetic agent cisapride in rat, rabbit and dog. Arzneimittelforschung 37, 1159–1167.

  25. Oparil, K.M., Gladden, J.N., Babyak, J.M., Lambert, C., Graham, J.E., 2019. Clinical characteristics and short-term outcomes for rabbits with signs of gastrointestinal tract dysfunction: 117 cases (2014-2016). J Am Vet Med Assoc 255, 837–845. https://doi.org/10.2460/javma.255.7.837

  26. Paul-Murphy, J., 2007. Critical Care of the Rabbit. Veterinary Clinics of North America: Exotic Animal Practice 10, 437–461. https://doi.org/10.1016/j.cvex.2007.03.002

  27. Remillard, R.L., 2002. Nutritional support in critical care patients. Veterinary Clinics of North America: Small Animal Practice 32, 1145–1164. https://doi.org/10.1016/S0195-5616(02)00050-5

  28. Reusch, B., 2005. Rabbit Gastroenterology. Veterinary Clinics of North America: Exotic Animal Practice 8, 351–375. https://doi.org/10.1016/j.cvex.2005.01.007

  29. Ritzman, T.K., 2014. Diagnosis and Clinical Management of Gastrointestinal Conditions in Exotic Companion Mammals (Rabbits, Guinea Pigs, and Chinchillas). Veterinary Clinics of North America: Exotic Animal Practice 17, 179–194. https://doi.org/10.1016/j.cvex.2014.01.003

  30. Robinson, N., Lyons, E., Grindlay, D., Brennan, M., 2017. Veterinarian Nominated Common Conditions of Rabbits and Guinea Pigs Compared with Published Literature. Veterinary Sciences 4, 58. https://doi.org/10.3390/vetsci4040058

  31. Sheptulin, A.A., Muradov, N.N., 1997. [A new prokinetic drug cisapride: pharmacological properties and clinical potential]. Klin Med (Mosk) 75, 53–56.

  32. Tack, J., Camilleri, M., Chang, L., Chey, W.D., Galligan, J.J., Lacy, B.E., Müller-Lissner, S., Quigley, E.M.M., Schuurkes, J., De Maeyer, J.H., Stanghellini, V., 2012. Systematic review: cardiovascular safety profile of 5-HT(4)  agonists developed for gastrointestinal disorders. Aliment. Pharmacol. Ther. 35, 745–767. https://doi.org/10.1111/j.1365-2036.2012.05011.x

  33. Tonini, M., De Ponti, F., Di Nucci, A., Crema, F., 1999. Review article: cardiac adverse effects of gastrointestinal prokinetics. Aliment. Pharmacol. Ther. 13, 1585–1591. https://doi.org/10.1046/j.1365-2036.1999.00655.x

  34. Torringa, M.L.J., van Roon, E.N., de Vries, T.W., 2003. CNS adverse effects of cisapride in children. Ann Pharmacother 37, 1344. https://doi.org/10.1345/aph.1C337

  35. Vandenplas, Y., 1998. Clinical use of cisapride and its risk-benefit in paediatric patients. Eur J Gastroenterol Hepatol 10, 871–881. https://doi.org/10.1097/00042737-199810000-00011

  36. Wangen, K., 2013. Therapeutic Review: Cisapride. Journal of Exotic Pet Medicine, Advanced Clinical Techniques 22, 301–304. https://doi.org/10.1053/j.jepm.2013.08.010

  37. Washabau, R.J., 2003. Gastrointestinal motility disorders and gastrointestinal prokinetic therapy. Veterinary Clinics of North America: Small Animal Practice, Gastroenterology 33, 1007–1028. https://doi.org/10.1016/S0195-5616(03)00076-7

  38. Wenger, S., Barrett, E.L., Pearson, G.R., Sayers, I., Blakey, C., Redrobe, S., 2009. Liver lobe torsion in three adult rabbits. Journal of Small Animal Practice 50, 301–305. https://doi.org/10.1111/j.1748-5827.2008.00719.x

  39. Wiseman, L.R., Faulds, D., 1994. Cisapride. An updated review of its pharmacology and therapeutic efficacy as a prokinetic agent in gastrointestinal motility disorders. Drugs 47, 116–152. https://doi.org/10.2165/00003495-199447010-00008

  40. Wu, M.-H., Su, M.-J., Sun, S.S.-M., 2003. Age-related differences in the direct cardiac effects of cisapride: narrower safety range in the hearts of young rabbits. Pediatr. Res. 53, 493–499. https://doi.org/10.1203/01.PDR.0000050122.67091.1D

Cisapride | Rabbit | Expert Opinion

  1. 1317822* |  220805 Extrapolation of pharmacological properties in man and veterinary species. Some  material employed in collating the data displayed here was taken from  veterinary product datasheets or extrapolated from pharmacology texts.


Last Updated by 1317822* | on 221012


Monograph Details

​

bottom of page