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Cefalexin

Grade

Sensitive Infections

Therapeutics

Evidence

  1. Bendirdjian, J.P., Prime, D.J., Browning, M.C., Hsu, C.Y., Tune, B.M., 1981. Additive nephrotoxicity of cephalosporins and aminoglycosides in the rabbit. J Pharmacol Exp Ther 218, 681–685.

  2. Berté, F., De Bernardi, M., Manzo, L., Benzi, G., 1972. Tissue distribution of cephalexin in pregnant rabbit and fetus after oral and intramuscular administration. Chemotherapy 17, 344–347. https://doi.org/10.1159/000220866

  3. Browning, M.C., Hsu, C.Y., Wang, P.L., Tune, B.M., 1983. Interaction of ischemic and antibiotic-induced injury in the rabbit kidney. J Infect Dis 147, 341–351. https://doi.org/10.1093/infdis/147.2.341

  4. Kramer, W., Girbig, F., Gutjahr, U., Kowalewski, S., Adam, F., Schiebler, W., 1992. Intestinal absorption of β-lactam antibiotics and oligopeptides. European Journal of Biochemistry 204, 923–930. https://doi.org/10.1111/j.1432-1033.1992.tb16713.x

  5. Licois, D., 1996. Risks related to antibiotic use in rabbit. World Rabbit Science 4, 63–68. https://doi.org/10.4995/wrs.1996.272

  6. Lumeij, J.T., Westerhof, I., van Sluijs, F.J., van Miert, A.S., 1987. [Lethal effects of various antimicrobial agents and clinically usable alternatives in rabbits and rodents]. Tijdschr Diergeneeskd 112, 1172–1176.

  7. Rougier, S., Galland, D., Boucher, S., Boussarie, D., Vallé, M., 2006. Epidemiology and susceptibility of pathogenic bacteria responsible for upper respiratory tract infections in pet rabbits. Vet Microbiol 115, 192–198. https://doi.org/10.1016/j.vetmic.2006.02.003

  8. Sakamoto, H., Hirose, T., Nakamoto, S., Hatano, K., Shibayama, F., Kikuchi, H., Mine, Y., Kuwahara, S., 1988. Pharmacokinetics of FK482, a new orally active cephalosporin, in animals. J Antibiot (Tokyo) 41, 1896–1905. https://doi.org/10.7164/antibiotics.41.1896

  9. Sugawara, M., Toda, T., Iseki, K., Miyazaki, K., Shiroto, H., Kondo, Y., Uchino, J.-I., 1992. Transport Characteristics of Cephalosporin Antibiotics Across Intestinal Brush-border Membrane in Man, Rat and Rabbit. Journal of Pharmacy and Pharmacology 44, 968–972. https://doi.org/10.1111/j.2042-7158.1992.tb07075.x

  10. Tune, B.M., Fravert, D., 1980. Cephalosporin nephrotoxicity. Transport, cytotoxicity and mitochondrial toxicity of cephaloglycin. J Pharmacol Exp Ther 215, 186–190.

  11. Welles, J.S., Froman, R.O., Gibson, W.R., Owen, N.V., Anderson, R.C., 1968. Toxicology and pharmacology of cephalexin in laboratory animals. Antimicrob Agents Chemother (Bethesda) 8, 489–496.

  12. Williams, P.D., Buening, M.K., Gries, C.L., Hanasono, G.K., Laska, D.A., Tamura, R.N., Heim, R.A., 1990. Comparative toxicity of oral cephalosporin antibiotics in the rabbit and in a rabbit kidney cell line (LLC-RK(1)). Toxicol In Vitro 4, 207–210. https://doi.org/10.1016/0887-2333(90)90023-m

  13. Yan, C.-Y., Liu, Y.-Z., Xu, Z.-H., Yang, H.-Y., Li, J., 2020. Comparison of Antibacterial Effect of Cationic Peptide LL-37 and Cefalexin on Clinical Staphylococcus aureus-induced Infection after Femur Fracture Fixation. Orthop Surg 12, 1313–1318. https://doi.org/10.1111/os.12754

Monograph Details

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